Fig. 1 · Structure
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ME3221
Angiotensin-converting Enzyme (ACE) Antagonist
ME3221 is a selective angiotensin-converting enzyme (ACE) antagonist that effectively inhibits the pressor response to angiotensin II, demonstrating significant antihypertensive activity in both renal hypertensive rats and spontaneously hypertensive rats (SHR). Its administration results in sustained and stable reductions in blood pressure without impacting heart rate, making ME3221 a valuable tool for research into renal and essential hypertension. This compound is ideal for studying the mechanisms underlying hypertension and evaluating therapeutic strategies for cardiovascular disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 139958-16-0 |
| Applications | Angiotensin-converting Enzyme (ACE) Antagonist |
| Formula | C22H21N5O2 |
| Molecular Weight | 387.43 |
| SMILES | COC1=C(C=C(C)N=C1C)OCC2=CC=C(C=C2)C3=C(C=CC=C3)C4=NN=NN4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.