Fig. 1 · Structure
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Melarsoprol
Anti-trypanosomiasis Agent
Melarsoprol is a melaminophenylarsine-derived trivalent organic arsenical that serves as a crucial anti-trypanosomiasis agent. It effectively targets and inhibits the growth of trypanosomes, the causative agents of African sleeping sickness, and induces apoptosis in lymphoid leukemic cells. Additionally, Melarsoprol has the capability to cross the blood-brain barrier, making it essential for treating central nervous system involvement in trypanosomiasis. Its application in both in vitro and in vivo studies enhances understanding of its therapeutic effects and mechanisms of action.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 494-79-1 |
| Applications | Anti-trypanosomiasis Agent |
| Formula | C12H15AsN6OS2 |
| Molecular Weight | 398.34 |
| SMILES | OCC1S[As](SC1)C2=CC=C(C=C2)NC3=NC(N)=NC(N)=N3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.