Fig. 1 · Structure
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MEN 11270
B2 Kinin Receptor Antagonist
MEN 11270 is a cyclic decapeptide that functions as a B2 kinin receptor antagonist. It demonstrates high-affinity binding to the B2 kinin receptor on WI38 human fibroblasts, effectively inhibiting 3H-bradykinin (BK) with a pKi value of 10.3. This compound is valuable for research applications exploring inflammatory pathways and the modulation of pain responses linked to kinin receptor activity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 235082-52-7 |
| Applications | B2 Kinin Receptor Antagonist |
| Formula | C60H90N20O11S |
| Molecular Weight | 1299.55 |
| SMILES | O=C1N2[C@@]3([C@](C[C@]2(C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC[C@H](NC([C@H](CC4=CC=CS4)NC(CNC(=O)[C@H]5N(C(=O)[C@H]6N(C([C@@H](NC([C@@H](CCCNC(=N)N)N)=O)CCCNC(=N)N)=O)CCC6)C[C@H](O)C5)=O)=O)C(=O)N7[C@@]1(CC=8C(C7)=CC=CC8)[H])[H])(CCCC3)[H])[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.