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Menin-MLL-IN-32

Menin-MLL Interaction Inhibitor

Menin-MLL-IN-32 is a potent inhibitor of the Menin-MLL interaction, exhibiting an IC50 of 0.042 nM in HTRF assays. This compound effectively inhibits MEIS1 mRNA expression with an IC50 of 11 nM and demonstrates significant anti-proliferative activity across diverse leukemia cell lines, with IC50 values of 8 nM in MOLM14, 24 nM in OCI-AML3, and 1900 nM in KO-52 cells. Menin-MLL-IN-32 serves as a valuable tool for investigating mechanisms in leukemia research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2879330-24-0
Applications	Menin-MLL Interaction Inhibitor
Formula	C₃₂H₄₂FN₅O₂
Molecular Weight	547.71
SMILES	CC(C)N(C)C(C1=C(C=CC(F)=C1)N2C3=CN=CC(C)=C3C(C[C@H]4CN(CC4)CC5CCN(CC5)C(C)=O)=C2)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.