Fig. 1 · Structure

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Mequitazine

Cat. No. A18206 CAS 29216-28-2

Histamine H1 antagonist

Mequitazine is a potent histamine H1 antagonist or antihistamine. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
Vero CC50 27.34 μM Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr 10.1101/2020.03.20.999730
Vero IC50 7.28 μM Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr 10.1101/2020.03.20.999730

Specifications

Manufacturer Adooq Bioscience
Actions Antagonist
CAS Number 29216-28-2
Applications Histamine H1 antagonist
Formula C20H22N2S
Molecular Weight 322.47
Synonyms Primalan; Mircol; Metaplexan; Virginan; Instotal; Quitadrill
SMILES
C1CN2CCC1C(C2)CN3C4=CC=CC=C4SC5=CC=CC=C53

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 29 mg/mL (89.93 mM)
Water Insoluble
Ethanol 28 mg/mL

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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