Fig. 1 · Structure
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Mer-NF5003F
Sesquiterpene
Mer-NF5003F is a sesquiterpene derived from Stachybotrys that primarily targets avian medulloblastoma virus (AMV) protease, exhibiting an IC50 of 7.8 μM. This compound demonstrates significant inhibitory effects on sialyltransferase 6N (ST6N), ST3O, and ST3N, with IC50 values of 0.61, 6.7, and 10 μg/mL, respectively, as well as fucosyltransferase (IC50=11.3 μg/mL). Additionally, Mer-NF5003F displays notable in vitro activity against herpes simplex virus HSV-1 (IC50=4.32 μg/mL) and the multidrug-resistant Plasmodium falciparum K1 strain (IC50=0.85 μg/mL), making it a valuable tool for antiviral and antiparasitic research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 149598-70-9 |
| Applications | Sesquiterpene |
| Formula | C23H30O5 |
| Molecular Weight | 386.48 |
| Synonyms | Stachybotrydial; F 1839M |
| SMILES | O[C@@H]1CC[C@]2([C@]([H])(C1(C)C)CC[C@H]([C@@]23OC4=C(C3)C(O)=CC(C=O)=C4C=O)C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.