Fig. 1 · Structure
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MET kinase-IN-3
MET Inhibitor
MET kinase-IN-3 is a potent inhibitor of the MET receptor tyrosine kinase, exhibiting an IC50 of 9.8 nM. This compound demonstrates significant antiproliferative activity across a range of cancer cell lines, making it a valuable tool for research in oncology and targeted therapies. Its oral bioavailability and efficacy position MET kinase-IN-3 as a promising candidate for further investigation in cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1446324-02-2 |
| Applications | MET Inhibitor |
| Formula | C25H16ClF2N5O2 |
| Molecular Weight | 491.88 |
| SMILES | NC1=NC=CC(OC2=C(C=C(C=C2)NC3=C4C(C(C5=CC=C(C=C5)F)=CNC4=CC=N3)=O)F)=C1Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.