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MET Transcription-IN-1

MET Transcription Inhibitor

MET Transcription-IN-1 is a potent MET transcription inhibitor that binds and stabilizes the G-quadruplex structure within the MET promoter region, leading to a reduction in c-Met expression. This compound effectively overcomes drug resistance associated with specific c-Met mutations and demonstrates significant inhibitory activity against tumor cell proliferation, migration, and invasion. Additionally, MET Transcription-IN-1 induces cell cycle arrest and apoptosis, making it a valuable reagent in research applications related to various tumors, including non-small cell lung cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3082125-66-1
Applications	MET Transcription Inhibitor
Formula	C₂₄H₁₆N₄O₂
Molecular Weight	392.41
SMILES	COC1=CC(C2=CC=C(O2)C(N3)=NC4=C3C(C=CC=N5)=C5C6=C4C=CC=N6)=CC=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.