Fig. 1 · Structure
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Metformin (glycinate)
Antihyperglycemic Drug
Metformin glycinate serves as an antihyperglycemic agent, primarily targeting mitochondrial respiratory chain activity in the liver. It activates AMP-activated protein kinase (AMPK), enhancing insulin sensitivity and glucose metabolism, making it valuable in type 2 diabetes research. Additionally, Metformin glycinate inhibits Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons, exerting central glucose-lowering effects. Its ability to mitigate liver oxidative stress, inflammation, and apoptosis during ischemia/reperfusion injury, along with modulating autophagy-related proteins via AMPK activation and mTOR inhibition, highlights its potential in cancer studies, particularly in renal cell carcinoma.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 121369-64-0 |
| Applications | Antihyperglycemic Drug |
| Formula | C6H16N6O2 |
| Molecular Weight | 204.23 |
| Synonyms | 1,1-Dimethylbiguanide (glycinate) |
| SMILES | O=C(CN)O.N=C(NC(N(C)C)=N)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.