Fig. 1 · Structure
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Methiothepin maleate
5-HT2 Antagonist
Methiothepin maleate is a potent and non-selective antagonist of the 5-HT2 receptor family, demonstrating affinity with pKis of 8.50 for 5-HT2A, 8.68 for 5-HT2B, and 8.35 for 5-HT2C. This compound effectively inhibits various serotonin receptor subtypes, including 5-HT1A through 5-HT7, making it a valuable tool for studying serotonin signaling pathways. Methiothepin maleate is commonly used in neuropharmacology research to investigate the role of serotonin in mood regulation, psychosis, and related disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 19728-88-2 |
| Applications | 5-HT2 Antagonist |
| Formula | C24H28N2O4S2 |
| Molecular Weight | 472.62 |
| Synonyms | Metitepine maleate; Ro-8-6837 maleate |
| SMILES | CN1CCN(C2CC3=CC=CC=C3SC4=CC=C(SC)C=C24)CC1.OC(/C=C\C(O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.