Methiothepin (Metitepine; Ro 8-6837) is a potent, non-selective antagonist of the 5-HT receptors, primarily targeting 5-HT2A, 5-HT2B, and 5-HT2C. It exhibits high affinity with pKi values of 8.50, 8.68, and 8.35 for these receptors, respectively. Methiothepin's antagonistic properties make it valuable for research in neuropharmacology, particularly in studies exploring serotonin signaling pathways and their implications in various mood disorders and psychotic conditions.
Methiothepin (Metitepine; Ro 8-6837) is a potent, non-selective antagonist of the 5-HT receptors, primarily targeting 5-HT2A, 5-HT2B, and 5-HT2C. It exhibits high affinity with pKi values of 8.50, 8.68, and 8.35 for these receptors, respectively. Methiothepin's antagonistic properties make it valuable for research in neuropharmacology, particularly in studies exploring serotonin signaling pathways and their implications in various mood disorders and psychotic conditions.
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