Fig. 1 · Structure
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Methiothepin
5-HT Receptor Antagonist
Methiothepin (Metitepine; Ro 8-6837) is a potent, non-selective antagonist of the 5-HT receptors, primarily targeting 5-HT2A, 5-HT2B, and 5-HT2C. It exhibits high affinity with pKi values of 8.50, 8.68, and 8.35 for these receptors, respectively. Methiothepin's antagonistic properties make it valuable for research in neuropharmacology, particularly in studies exploring serotonin signaling pathways and their implications in various mood disorders and psychotic conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 20229-30-5 |
| Applications | 5-HT Receptor Antagonist |
| Formula | C20H24N2S2 |
| Molecular Weight | 356.55 |
| Synonyms | Metitepine; Ro 8-6837 |
| SMILES | CN1CCN(C2CC3=CC=CC=C3SC4=CC=C(SC)C=C24)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.