Fig. 1 · Structure
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Methotrexate-alpha-alanine
Prodrug
Methotrexate-alpha-alanine is a prodrug designed for activation by enzyme-monoclonal antibody conjugates. It exhibits notable cytotoxicity, making it a valuable tool for targeted cancer therapies. This compound is utilized in research to investigate selective drug delivery mechanisms and enhance therapeutic efficacy in oncology applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 116819-28-4 |
| Applications | Prodrug |
| Formula | C23H27N9O6 |
| Molecular Weight | 525.52 |
| SMILES | NC1=NC(N)=NC2=C1N=C(CN(C3=CC=C(C=C3)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(O)=O)=O)=O)C)C=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.