Fig. 1 · Structure
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Methotrexate-d3
Stable Isotope
Methotrexate-d3 is a deuterium-labeled form of Methotrexate, an antimetabolite and antifolate agent that selectively inhibits dihydrofolate reductase. This inhibition disrupts the conversion of folic acid to tetrahydrofolate, effectively blocking DNA synthesis. Methotrexate-d3 serves as a valuable tool in research applications related to rheumatoid arthritis and various cancers, including acute lymphoblastic leukemia, enabling studies on drug metabolism and therapeutic efficacy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 432545-63-6 |
| Applications | Stable Isotope |
| Formula | C20H19D3N8O5 |
| Molecular Weight | 457.46 |
| SMILES | NC1=NC(N)=NC2=C1N=C(CN(C3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C3)C([2H])([2H])[2H])C=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.