Fig. 1 · Structure
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Methoxyamine hydrochloride
BER Inhibitor
Methoxyamine hydrochloride is a potent inhibitor of base excision repair (BER) that targets and binds to 3’ hydroxyl groups generated by 3-methylpurine-DNA glycosylase (MPG) during the excision process. By directly interacting with apyrimidinic (AP) sites, Methoxyamine hydrochloride effectively inhibits BER activity. This compound is essential for research into enhancing the therapeutic effects of DNA-damaging agents, offering potential applications in cancer treatment and related studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 593-56-6 |
| Applications | BER Inhibitor |
| Formula | CH6ClNO |
| Molecular Weight | 83.52 |
| Synonyms | O-Methylhydroxylamine hydrochloride |
| SMILES | NOC.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.