Fig. 1 · Structure
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Methyl cholate
TcdB Inhibitor
Methyl cholate is a bile acid analog that acts as a specific inhibitor of the TcdB toxin from Clostridioides difficile. It demonstrates a stronger selective inhibitory effect on TcdB compared to TcdA, facilitating conformational stabilization by binding to a unique site on TcdB. This action prevents the toxin from attaching to host receptors and undergoing self-processing, offering protection to human fibroblasts from TcdB-induced cytopathic effects. Methyl cholate also exhibits dose-dependent anti-hepatic fibrosis activity in cellular and zebrafish models by significantly reducing the expression of α-SMA and COL-I, making it valuable for research in Clostridioides difficile infections and hepatic fibrosis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1448-36-8 |
| Applications | TcdB Inhibitor |
| Formula | C25H42O5 |
| Molecular Weight | 422.60 |
| SMILES | O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@]([C@H](C)CCC(OC)=O)([H])CC3)([C@@H](O)C[C@]2([H])[C@]4(C)[C@](C[C@H](O)CC4)([H])C1)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.