Fig. 1 · Structure
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Methyl succinate
Mitochondrial Complex II Substrate
Methyl succinate is a substrate for mitochondrial Complex II, facilitating electron transfer by bypassing Complex I inhibition. This compound has shown the ability to restore mitochondrial function and reduce AMPK phosphorylation, demonstrating protective effects on MIN6 β-cells and primary rat β-cells against biguanide-induced toxicity and apoptosis in vitro. Methyl succinate is valuable for research applications related to metabolic disorders, particularly in the study of diabetes mellitus.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Substrate |
| CAS Number | 3878-55-5 |
| Applications | Mitochondrial Complex II Substrate |
| Formula | C5H8O4 |
| Molecular Weight | 132.11 |
| SMILES | O=C(CCC(OC)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.