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Methylbiocin

CMG Helicase Inhibitor

Methylbiocin is an ATP-competitive inhibitor that targets human CMG helicase, demonstrating an IC50 of 59 µM. This compound exhibits significant potential for research applications in cancer biology by interfering with the helicase activity crucial for DNA replication and repair. Methylbiocin may serve as a valuable tool for investigating the molecular mechanisms underlying cancer progression and therapeutic resistance.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	23370-12-9
Applications	CMG Helicase Inhibitor
Formula	C₃₆H₄₀N₂O₁₁
Molecular Weight	676.71
SMILES	CC1=C(O[C@H]2[C@H](O)[C@H](OC(C3=CC=C(C)N3)=O)[C@@H](OC)C(C)(C)O2)C=CC4=C1OC(C(NC(C5=CC(C/C=C(C)/C)=C(O)C=C5)=O)=C4O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.