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Methyllycaconitine

Catalog No.: A67679
α7nAChR Antagonist
Methyllycaconitine is a selective competitive antagonist of the α7 nicotinic acetylcholine receptor (α7nAChR). It demonstrates significant neuroprotective effects by alleviating cytotoxicity induced by amyloid-β peptides in SH-SY5Y cells and mitigating methamphetamine-induced effects in the mouse striatum. Methyllycaconitine is a valuable tool for research into neurological disorders, including Alzheimer's disease.
Methyllycaconitine 21019-30-7 α7nAChR Antagonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMethyllycaconitine is a selective competitive antagonist of the α7 nicotinic acetylcholine receptor (α7nAChR). It demonstrates significant neuroprotective effects by alleviating cytotoxicity induced by amyloid-β peptides in SH-SY5Y cells and mitigating methamphetamine-induced effects in the mouse striatum. Methyllycaconitine is a valuable tool for research into neurological disorders, including Alzheimer's disease.
Product Information
Catalog NumA67679
FormulaC37H50N2O10
Molecular Weight682.80
CAS Number21019-30-7
SMILESCO[C@@H]1[C@@]23[C@@]4([H])[C@](CN([C@]2([H])[C@]([C@H]4OC)([C@@]5([C@]6([H])[C@@]3([H])C[C@@]([C@H](C5)OC)([H])[C@@H]6OC)O)O)CC)(CC1)COC(C7=C(N8C(C[C@@H](C8=O)C)=O)C=CC=C7)=O
SynonymsMLA
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Neuronal Signaling > nAChR