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Methyllycaconitine

α7nAChR Antagonist

Methyllycaconitine is a selective competitive antagonist of the α7 nicotinic acetylcholine receptor (α7nAChR). It demonstrates significant neuroprotective effects by alleviating cytotoxicity induced by amyloid-β peptides in SH-SY5Y cells and mitigating methamphetamine-induced effects in the mouse striatum. Methyllycaconitine is a valuable tool for research into neurological disorders, including Alzheimer's disease.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	21019-30-7
Applications	α7nAChR Antagonist
Formula	C₃₇H₅₀N₂O₁₀
Molecular Weight	682.80
Synonyms	MLA
SMILES	CO[C@@H]1[C@@]23[C@@]4([H])[C@](CN([C@]2([H])[C@]([C@H]4OC)([C@@]5([C@]6([H])[C@@]3([H])C[C@@]([C@H](C5)OC)([H])[C@@H]6OC)O)O)CC)(CC1)COC(C7=C(N8C(C[C@@H](C8=O)C)=O)C=CC=C7)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.