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Biological Activity
MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.4 mL | 131.99 mL | 263.98 mL |
| 0.5 mM | 5.28 mL | 26.4 mL | 52.8 mL |
| 1 mM | 2.64 mL | 13.2 mL | 26.4 mL |
| 5 mM | 0.53 mL | 2.64 mL | 5.28 mL |
*The above data is based on the productmolecular weight 378.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11488 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 892549-43-8 |
| Formula | C23H11ClN4 |
| M. Wt | 378.81 |
| Purity | >98% |
| Synonyms | MF 63, MF-63 |
| SMILES | C1=CC=C2C(=C1)C3=C(C=CC(=C3)Cl)C4=C2N=C(N4)C5=C(C=CC=C5C#N)C#N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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