Fig. 1 · Structure
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MG-277
PROTAC GSPT1 Degrader
MG-277 is a PROTAC GSPT1 degrader that induces degradation of the translation termination factor GSPT1 via a Cereblon E3 ligase mechanism, with a DC50 of 1.3 nM. This compound exhibits potent anticancer activity, significantly inhibiting tumor cell growth in a p53-independent manner, demonstrating IC50 values of 3.5 nM for RS4;11 cells and 3.4 nM for p53 mutant RS4;11/IRMI-2 cells. MG-277 is a valuable tool for cancer research, particularly in studies involving protein degradation and cellular mechanisms of tumorigenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2411085-89-5 |
| Applications | PROTAC GSPT1 Degrader |
| Formula | C41H42Cl2FN5O5 |
| Molecular Weight | 774.71 |
| SMILES | ClC1=CC=C2C(NC([C@@]23C4(N[C@H]([C@@H]3C5=CC=CC(Cl)=C5F)C(NCCCCCC6=C(C7=CC=C6)CN(C7=O)C8C(NC(CC8)=O)=O)=O)CCCCC4)=O)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.