Fig. 1 · Structure
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mGAT3/4-IN-1
mGAT3/mGAT4 Inhibitor
mGAT3/4-IN-1 is a potent inhibitor of the mGAT3 and mGAT4 transporters, with pIC50 values of 5.31 and 5.24, respectively. This compound demonstrates significant analgesic effects, particularly in reducing tactile allodynia in diabetic neuropathic mice. It is a valuable tool for research on pain mechanisms and potential therapies for neuropathic pain conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2556833-57-7 |
| Applications | mGAT3/mGAT4 Inhibitor |
| Formula | C26H31ClN2O2S2 |
| Molecular Weight | 503.12 |
| SMILES | O=C(C(CCO)N(CC/C=C(C1=C(C)C=CS1)\C2=C(C)C=CS2)C)NCC3=C(Cl)C=CC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.