mGluR2 modulator 3 is a potent positive allosteric modulator (PAM) of the metabotropic glutamate receptor 2 (mGluR2), exhibiting an EC50 value of 0.87 μM. This compound demonstrates significant biological activity in preclinical models of psychotic disorders, including methamphetamine-induced hyperactivity and mescaline-induced scratching in mice. It is a valuable reagent for researching the modulation of mGluR2 in the context of neuropsychiatric diseases.
mGluR2 modulator 3 is a potent positive allosteric modulator (PAM) of the metabotropic glutamate receptor 2 (mGluR2), exhibiting an EC50 value of 0.87 μM. This compound demonstrates significant biological activity in preclinical models of psychotic disorders, including methamphetamine-induced hyperactivity and mescaline-induced scratching in mice. It is a valuable reagent for researching the modulation of mGluR2 in the context of neuropsychiatric diseases.
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