Fig. 1 · Structure
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mGluR2 modulator 5
mGluR2 modulator
mGluR2 modulator 5 is a selective negative allosteric modulator of the mGluR2 receptor, exhibiting an IC50 of 8.9 nM. This compound is orally active and demonstrates the ability to cross the blood-brain barrier, as confirmed by pharmacokinetic studies in rats. Its modulation of cognitive and neurological functions makes it a valuable tool for investigating mood disorders and neurodegenerative diseases in preclinical research settings.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1639898-35-3 |
| Applications | mGluR2 modulator |
| Formula | C20H17F3N4O |
| Molecular Weight | 386.37 |
| SMILES | CC1=NC=CC(C2=C(C(N(C3=CC=C(C(F)(F)F)C=C3)C[C@@H]4C)=O)N4N=C2)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.