mGluR2 modulator 6

Catalog No.: A61885
mGluR2 Modulator
mGluR2 modulator 6 is a selective modulator of the metabotropic glutamate receptor 2 (mGluR2), exhibiting significant anticonvulsant activity in the 6Hz epilepsy model. This compound has demonstrated enhanced efficacy when used in combination with Levetiracetam. It serves as a valuable tool for investigating the mechanisms underlying epilepsy and potential therapeutic strategies.
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5mg
10mg
50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionmGluR2 modulator 6 is a selective modulator of the metabotropic glutamate receptor 2 (mGluR2), exhibiting significant anticonvulsant activity in the 6Hz epilepsy model. This compound has demonstrated enhanced efficacy when used in combination with Levetiracetam. It serves as a valuable tool for investigating the mechanisms underlying epilepsy and potential therapeutic strategies.
Product Information
Catalog NumA61885
FormulaC20H23ClF2N2O
Molecular Weight380.86
CAS Number1127498-73-0
SMILESO=C1C(Cl)=C(N2CCC(CC2)C3=CC=C(C=C3F)F)C=CN1CCCC
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