Fig. 1 · Structure
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mGluR5 antagonist-1
mGluR5 Antagonist
mGluR5 antagonist-1 is a potent orally active antagonist of the metabotropic glutamate receptor 5 (mGluR5), exhibiting an IC50 value of 11.5 nM. This compound demonstrates notable antidepressant effects, making it a valuable tool for investigating the pathophysiology of depressive disorders. Researchers can utilize mGluR5 antagonist-1 to explore therapeutic strategies for depression and related neurological conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 2761424-76-2 |
| Applications | mGluR5 Antagonist |
| Formula | C23H18N4O2 |
| Molecular Weight | 382.41 |
| SMILES | CN1C2=NC=NC(C#CC3=CC=CC=C3)=C2C=C1C(NC4=CC=C(OC)C=C4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.