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MGS0008

mGlu2/3 Agonist

MGS0008 is a potent and orally bioavailable agonist of the metabotropic glutamate receptors 2 and 3 (mGlu2/3), exhibiting EC50 values of 29.4 nM and 45.4 nM, respectively. This compound demonstrates significant biological activity in modulating glutamatergic neurotransmission and holds potential for advancing research in central nervous system disorders, including schizophrenia, anxiety, and neurodegenerative diseases. MGS0008 serves as a valuable tool for investigating therapeutic strategies targeting mGlu2 and mGlu3 receptors.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	234085-20-2
Applications	mGlu2/3 Agonist
Formula	C₈H₁₀FNO₄
Molecular Weight	203.17
SMILES	O=C([C@@]1(N)[C@]2([H])[C@@H](C(O)=O)[C@]2([H])C[C@@H]1F)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.