Fig. 1 · Structure
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MGS0039
mGluR Antagonist
MGS0039 is a type II group metabotropic glutamate receptor (mGluR) antagonist that exhibits high affinity for mGluR2 and mGluR3, with Ki values of 2.2 nM and 4.5 nM, respectively. This compound effectively inhibits glutamate-induced cyclic AMP formation in CHO cells expressing these receptors, suggesting its potential utility in modulating glutamatergic signaling. Additionally, MGS0039 demonstrates antidepressant-like effects in rat models, highlighting its relevance for research in neuropharmacology and mood disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 569686-87-9 |
| Applications | mGluR Antagonist |
| Formula | C15H14Cl2FNO5 |
| Molecular Weight | 378.18 |
| Synonyms | BCI 632 |
| SMILES | O=C(O)[C@]1([C@@]2([C@](F)([C@@]2(C[C@H]1OCC3=CC=C(C(Cl)=C3)Cl)[H])C(O)=O)[H])N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.