Fig. 1 · Structure
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MI-1
Epigenetic Reader Domain Inhibitor
MI-1 is an epigenetic reader domain inhibitor that disrupts the Menin-MLL interaction, exhibiting an IC50 of 1.9 μM. This compound plays a critical role in modulating gene expression associated with chromatin remodeling and has been implicated in cancer research, particularly in treating mixed lineage leukemia (MLL) driven malignancies. Its utility in cellular models provides valuable insights into epigenetic regulation and therapeutic strategies for MLL-related disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 433311-07-0 |
| Applications | Epigenetic Reader Domain Inhibitor |
| Formula | C19H25N5S2 |
| Molecular Weight | 387.57 |
| SMILES | CC1(C)CN=C(N2CCN(C3=C(C4=C(CCCC4)S5)C5=NC=N3)CC2)S1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.