Fig. 1 · Structure
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MI-1481
Menin-MLL1 Interaction Inhibitor
MI-1481 is a potent inhibitor of the Menin-MLL1 interaction, exhibiting an IC50 value of 3.6 nM. This compound effectively reduces the proliferation of murine bone marrow cells that have undergone transformation and demonstrates significant inhibitory effects on leukemia progression. MI-1481 is valuable for research applications targeting MLL-rearranged leukemias and studies related to gene expression regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1887178-64-4 |
| Applications | Menin-MLL1 Interaction Inhibitor |
| Formula | C29H30F3N7O2S |
| Molecular Weight | 597.65 |
| SMILES | N#CC(N1C[C@@H](OC2)CNC2=O)=CC3=C1C=CC(CN4CCC(NC5=C(C=C(CC(F)(F)F)S6)C6=NC=N5)CC4)=C3C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.