MI-389 is a PROTAC degrader targeting the translation termination factor GSPT1. Its activity relies on recruitment of the CRL4^CRBN E3 ubiquitin ligase complex to induce selective degradation of GSPT1. MI-389 effectively disrupts a critical dependency shared across multiple acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) cell lines, making it a promising therapeutic candidate for hematologic malignancies characterized by GSPT1 dependence.
MI-389 is a PROTAC degrader targeting the translation termination factor GSPT1. Its activity relies on recruitment of the CRL4^CRBN E3 ubiquitin ligase complex to induce selective degradation of GSPT1. MI-389 effectively disrupts a critical dependency shared across multiple acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) cell lines, making it a promising therapeutic candidate for hematologic malignancies characterized by GSPT1 dependence.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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