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MI891

PXR Antagonist/Inverse Agonist

MI891 is a highly selective PXR antagonist and inverse agonist, demonstrating an IC50 of 3.76 μM and 6.1 μM, respectively. It effectively disrupts the interaction between PXR and its coactivator SRC1, inhibiting Rifampicin-induced PXR activation. MI891 is instrumental in researching metabolic disorders and other related diseases, providing insights into PXR signaling pathways and their implications in pharmacology and toxicology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	2530027-77-9
Applications	PXR Antagonist/Inverse Agonist
Formula	C₂₃H₁₄Cl₂F₂N₆O
Molecular Weight	499.30
SMILES	O=C(N)C1=CC(CN2N=NC(C3=C(C4=CC=C(Cl)C=C4)N=C5C(F)=CC(F)=CN53)=C2)=CC=C1Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.