Fig. 1 · Structure
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Microcolin H
PITPα/β Ligand
Microcolin H is a marine lipopeptide that acts as a ligand for phosphatidylinositol transfer protein α and β (PITPα/β). It promotes the conversion of LC3I to LC3II while decreasing p62 levels in cancer cells, which enhances autophagic cell death. Additionally, Microcolin H demonstrates significant anti-proliferative effects and effectively inhibits tumor growth in nude mouse subcutaneous tumor models, making it valuable for research in cancer biology and autophagy pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2408008-21-7 |
| Applications | PITPα/β Ligand |
| Formula | C38H63N5O9 |
| Molecular Weight | 733.93 |
| SMILES | O=C(N1[C@H](C=CC1=O)C)[C@H]2N(C[C@H](C2)O)C([C@H](C(C)C)N(C)C([C@H]([C@@H](C)OC(C)=O)NC([C@H](CC(C)C)N(C)C([C@H](C)CCCCCC)=O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.