Fig. 1 · Structure
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Midaglizole hydrochloride
α2-Adrenoceptor Antagonist
Midaglizole hydrochloride is a preferential α2-adrenoceptor antagonist, exhibiting a significantly greater affinity for the α2-adrenoceptor compared to the α1-adrenoceptor, with a pKi of 6.28. This selective mechanism allows for the modulation of adrenergic signaling pathways, making it a valuable tool for studying the physiological roles of α2-adrenoceptors. Midaglizole hydrochloride is applicable in research focused on cardiovascular effects, neuropharmacology, and the treatment of various conditions related to adrenergic dysregulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 79689-25-1 |
| Applications | α2-Adrenoceptor Antagonist |
| Formula | C16H19Cl2N3 |
| Molecular Weight | 324.25 |
| Synonyms | (±)-DG5128; DG5128 |
| SMILES | C(C1=CC=CC=C1)(C2=CC=CC=N2)CC3=NCCN3.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.