Fig. 1 · Structure
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Milvexian TFA
Factor Xia Antagonist
Milvexian TFA is a selective factor XIa inhibitor that effectively prevents venous thromboembolism. This compound has demonstrated efficacy in reducing venous thromboembolism rates in patients undergoing knee replacement surgery. Additionally, Milvexian TFA exhibits significant inhibitory activity against plasma kallikrein and trypsin, with a favorable bioavailability of 32%. Clinical trials indicate that Milvexian TFA presents a relatively low risk of bleeding, making it a promising candidate for further research in thrombotic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1802426-00-1 |
| Applications | Factor Xia Antagonist |
| Formula | C30H24Cl2F5N9O4 |
| Molecular Weight | 740.47 |
| Synonyms | BMS-986177 TFA; JNJ-70033093 TFA |
| SMILES | O=C(NC1=C2N(C(F)F)N=C1)[C@H](C)CCC[C@H](N(C=NC(C3=CC(Cl)=CC=C3N4N=NC(Cl)=C4)=C5)C5=O)C6=CC2=CC=N6.OC(C(F)(F)F)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.