Fig. 1 · Structure
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Milvexian
Factor Xia Antagonist
Milvexian is a small-molecule inhibitor targeting Factor Xia, functioning as a reversible, direct antagonist. It exhibits an impressive binding affinity, with Ki values of 0.11 nM for human, 0.38 nM for rabbit, 0.64 nM for dog, and 490 nM and 350 nM for rat and mouse, respectively. Milvexian demonstrates significant anti-thrombotic activity both in vitro and in vivo, making it a valuable tool for studying thrombus formation and related cardiovascular disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1802425-99-5 |
| Applications | Factor Xia Antagonist |
| Formula | C28H23Cl2F2N9O2 |
| Molecular Weight | 626.44 |
| Synonyms | BMS-986177; JNJ-70033093 |
| SMILES | O=C(NC1=C2N(C(F)F)N=C1)[C@H](C)CCC[C@H](N(C=NC(C3=CC(Cl)=CC=C3N4N=NC(Cl)=C4)=C5)C5=O)C6=CC2=CC=N6 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.