Fig. 1 · Structure
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MIPS521
A1AR Positive Allosteric Modulator
MIPS521 is a positive allosteric modulator of the adenosine A1 receptor (A1AR). It demonstrates a lower allosteric affinity for A1AR (pKB=4.95; KB=11 μM) and is known to exert analgesic effects in vivo by enhancing the levels of endogenous adenosine. This compound is useful for research on pain management and the role of adenosine signaling in various physiological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1146188-19-3 |
| Applications | A1AR Positive Allosteric Modulator |
| Formula | C19H10ClF6NOS |
| Molecular Weight | 449.80 |
| SMILES | O=C(C1=C(N)SC=C1C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C3=CC=C(C=C3)Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.