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Mipsagargin

Thapsigargin Prodrug

Mipsagargin is a thapsigargin-based prodrug that targets the prostate-specific membrane antigen (PSMA). This compound is designed to selectively release the potent SERCA pump inhibitor thapsigargin upon PSMA-mediated cleavage of an inert masking peptide. Mipsagargin demonstrates significant potential for the treatment of refractory advanced or metastatic solid tumors, making it a valuable tool for cancer research applications focused on targeted therapies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1245732-48-2
Applications	Thapsigargin Prodrug
Formula	C₆₆H₁₀₀N₆O₂₇
Molecular Weight	1409.52
Synonyms	G-202
SMILES	CC1=C2[C@]([C@H](OC(CCCCCCC)=O)[C@H]1OC(/C(=C\C)/C)=O)([C@](OC(C)=O)(C)C[C@H](OC(CCCCCCCCCCCNC(C[C@@H](C(N[C@@H](CCC(N[C@@H](CCC(N[C@@H](CCC(N[C@@H](CCC(O)=O)C(O)=O)=O)C(O)=O)=O)C(O)=O)=O)C(O)=O)=O)N)=O)=O)[C@@]3(O)[C@]2(OC(=O)[C@@]3(C)O)[H])[H]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.