Mitapivat hemisulfate sesquihydrate is an orally active allosteric activator of pyruvate kinase (PK). This compound enhances enzymatic activity and protein stability while increasing ATP levels across various PKLR genotypes. Mitapivat is instrumental in studying pyruvate kinase deficiencies and has significant implications for restoring glycolytic pathway activity in affected cells.
Mitapivat hemisulfate sesquihydrate is an orally active allosteric activator of pyruvate kinase (PK). This compound enhances enzymatic activity and protein stability while increasing ATP levels across various PKLR genotypes. Mitapivat is instrumental in studying pyruvate kinase deficiencies and has significant implications for restoring glycolytic pathway activity in affected cells.
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