Fig. 1 · Structure
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Mitapivat hemisulfate sesquihydrate
Cat. No.
A77419
CAS
2151847-10-6
Pyruvate Kinase Activator
Mitapivat hemisulfate sesquihydrate is an orally active allosteric activator of pyruvate kinase (PK). This compound enhances enzymatic activity and protein stability while increasing ATP levels across various PKLR genotypes. Mitapivat is instrumental in studying pyruvate kinase deficiencies and has significant implications for restoring glycolytic pathway activity in affected cells.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 2151847-10-6 |
| Applications | Pyruvate Kinase Activator |
| Formula | C24H26N4O3S.1/2H2SO4.3/2H2O |
| Molecular Weight | 526.62 |
| Synonyms | AG-348 hemisulfate sesquihydrate |
| SMILES | O=C(N1CCN(CC2CC2)CC1)C3=CC=C(NS(=O)(C4=CC=CC5=CC=CN=C54)=O)C=C3.O=S(O)(O)=O.O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.