Fig. 1 · Structure
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Mitiglinide
K(ATP) Channel Antagonist
Mitiglinide is an ATP-sensitive potassium (KATP) channel antagonist that primarily targets the Kir6.2/SUR1 complex, which is integral to pancreatic beta-cell function. This compound exhibits insulinotropic properties, making it relevant for research into type 2 diabetes management. Mitiglinide’s specificity for KATP channels allows for exploration of its effects on insulin secretion and glucose homeostasis in diabetic models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 145375-43-5 |
| Applications | K(ATP) Channel Antagonist |
| Formula | C19H25NO3 |
| Molecular Weight | 315.41 |
| Synonyms | KAD-1229 free acid anhydrous; S21403 free acid anhydrous |
| SMILES | O=C(N1C[C@@](CCCC2)([H])[C@@]2([H])C1)C[C@@H](C(O)=O)CC3=CC=CC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.