Fig. 1 · Structure
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Mitoguazone
S-adenosyl-methionine Decarboxylase Inhibitor
Mitoguazone, a competitive inhibitor of S-adenosyl-methionine decarboxylase, exhibits significant antineoplastic properties through the disruption of polyamine biosynthesis. This brain-penetrant synthetic polycarbonyl derivative induces apoptosis in cancer cells and demonstrates inhibitory effects on HIV DNA integration in both monocytes and macrophages. Mitoguazone is a candidate for research applications related to acute leukemia and both Hodgkin's and non-Hodgkin's lymphoma treatment.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 459-86-9 |
| Applications | S-adenosyl-methionine Decarboxylase Inhibitor |
| Formula | C5H12N8 |
| Molecular Weight | 184.20 |
| Synonyms | Methylglyoxal-bis(guanylhydrazone); MGBG; Methyl-GAG |
| SMILES | CC(/C=N/NC(N)=N)=N\NC(N)=N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.