Fig. 1 · Structure
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Mitoxantrone diacetate
Top II/PKC Inhibitor
Mitoxantrone diacetate is a potent inhibitor of topoisomerase II and also exhibits inhibition of protein kinase C (PKC) with an IC50 of 8.5 μM. This compound induces apoptosis in B-chronic lymphocytic leukaemia (B-CLL) cells, demonstrating significant antitumor activity. Additionally, Mitoxantrone diacetate shows effective anti-orthopoxvirus activity, with EC50 values of 0.25 μM for cowpox and 0.8 μM for monkeypox, making it valuable in studies related to viral infections and cancer therapy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 70711-41-0 |
| Applications | Top II/PKC Inhibitor |
| Formula | C26H36N4O10 |
| Molecular Weight | 564.58 |
| Synonyms | Mitozantrone diacetate; NSC 301739 diacetate |
| SMILES | O=C1C2=C(C(NCCNCCO)=CC=C2NCCNCCO)C(C3=C(O)C=CC(O)=C13)=O.O=C(C)O.O=C(C)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.