Fig. 1 · Structure
Documents & Downloads
MK-0249
H3 Receptor Antagonist
MK-0249 is a potent, selective, and orally active histamine H3 receptor antagonist, exhibiting an IC50 of 1.7 nM for the human H3 receptor. This compound demonstrates significant biological activity in modulating neurotransmitter release and is valuable for research applications involving cognitive function, sleep regulation, and neurodegenerative disorders. MK-0249 serves as a critical tool for exploring the therapeutic potential of H3 receptor inhibition in various neurological conditions.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 862309-06-6 |
| Applications | H3 Receptor Antagonist |
| Formula | C23H24F3N3O2 |
| Molecular Weight | 431.45 |
| SMILES | O=C1N(C2=CC=C(OCCCN3CCCC3)C=C2)C(C)=NC4=C1C(C(F)(F)F)=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.