Fig. 1 · Structure
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MK-0668 mesylate
VLA-4 Antagonist
MK-0668 mesylate is a potent antagonist of unactivated VLA-4, demonstrating an IC50 of 0.13 nM in human whole blood. This compound also exhibits high affinity across species, with IC50 values of 0.19 nM in dogs, 0.21 nM in rhesus monkeys, and 0.4 nM in rats. MK-0668 mesylate is valuable for research focused on inflammatory diseases and immune modulation, making it a critical tool in drug discovery and development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 865111-04-2 |
| Applications | VLA-4 Antagonist |
| Formula | C32H34Cl2N6O9S2 |
| Molecular Weight | 781.68 |
| SMILES | O=C([C@@H](NC([C@H]1N(C[C@@H](C1)NC2CCC2)S(=O)(C3=CC=CC(C#N)=C3)=O)=O)CC4=CC=C(C=C4)NC(C5=C(C=NC=C5Cl)Cl)=O)O.CS(=O)(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.