Fig. 1 · Structure
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MK 0686
Bradykinin Receptor
MK 0686 is a potent antagonist of the bradykinin B1 receptor, primarily utilized for investigating inflammatory and pain pathways. This compound exhibits autoinduction of its own metabolism, particularly through the upregulation of CYP2C75, which results in significant biotransformation and the formation of metabolites such as M11 and M13. Research involving MK 0686 may provide insights into its pharmacokinetics and systemic exposure, emphasizing its relevance in studies of pain modulation and therapeutic interventions targeting the bradykinin system.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 578727-68-1 |
| Applications | Bradykinin Receptor |
| Formula | C22H19ClF4N2O4 |
| Molecular Weight | 486.84 |
| SMILES | O=C(C(F)(F)F)NC1(C(N[C@H](C)C2=C(F)C=C(C3=CC=CC(Cl)=C3C(OC)=O)C=C2)=O)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.