Fig. 1 · Structure
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MK-0731
KSP Inhibitor
MK-0731 is a selective, non-competitive allosteric inhibitor of kinesin spindle protein (KSP), demonstrating an IC50 of 2.2 nM and a pKa of 7.6. With over 20,000-fold selectivity for KSP compared to other kinesins, MK-0731 effectively induces mitotic arrest and promotes apoptosis in tumor cells. This compound shows significant antitumor efficacy, making it a valuable tool for cancer research and therapeutic applications targeting cell division and tumor growth.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 845256-65-7 |
| Applications | KSP Inhibitor |
| Formula | C25H28F3N3O2 |
| Molecular Weight | 459.50 |
| SMILES | O=C(N(C)[C@@H](CC1)[C@H](F)CN1C)N2[C@@](C3=CC=CC=C3)(CO)C=C(C4=CC(F)=CC=C4F)C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.