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MK-571 is a selective, orally active CysLT1 receptor antagonist. It blocks the binding of LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively.
Targets
| CysLT1 | MRP1 | MRP4 | cMOAT | |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.62 mL | 93.1 mL | 186.2 mL |
| 0.5 mM | 3.72 mL | 18.62 mL | 37.24 mL |
| 1 mM | 1.86 mL | 9.31 mL | 18.62 mL |
| 5 mM | 0.37 mL | 1.86 mL | 3.72 mL |
*The above data is based on the productmolecular weight 537.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15983 |
|---|---|
| Actions | Antagonist |
| M. Wt | 537.06 |
| Formula | C26H26ClN2NaO3S2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 115103-85-0 |
| Synonyms | L-660,711, L660,711, L 660,711, L-660711 |
| SMILES | O=C([O-])CCSC(C1=CC=CC(/C=C/C2=NC3=CC(Cl)=CC=C3C=C2)=C1)SCCC(N(C)C)=O.[Na+] |
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