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MK-7725

BRS-3 Agonist

MK-7725 is a selective agonist of the bradykinin receptor subtype 3 (BRS-3), demonstrating high affinity for human BRS-3 with an IC50 of 3 nM. This compound effectively activates mouse-derived BRS-3 with an EC50 of 22 nM, exhibiting robust agonistic activity. MK-7725 has been shown to significantly reduce body weight in obese rat and dog models, supporting its potential applications in obesity treatment and metabolic research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	1034152-93-6
Applications	BRS-3 Agonist
Formula	C₂₅H₁₉F₆N₅O₅S
Molecular Weight	615.50
SMILES	O=S(N1C2=C(C3=NOC(C(C)(O)C)=N3)C=CC=C2NC4=NC(C(F)(F)F)=CC=C4C1)(C5=CC=C(OC(F)(F)F)C=C5)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.