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Biological Activity
MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.
| In vitro | DMSO | Warmed: 17 mg/mL (38.34 mM) | |
| Water | Insoluble | ||
| Ethanol | 1 mg/mL (2.25 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.55 mL | 112.75 mL | 225.5 mL |
| 0.5 mM | 4.51 mL | 22.55 mL | 45.1 mL |
| 1 mM | 2.26 mL | 11.28 mL | 22.55 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.51 mL |
*The above data is based on the productmolecular weight 443.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12618 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1187990-87-9 |
| Formula | C24H21N5O4 |
| M. Wt | 443.45 |
| Purity | >98% |
| Synonyms | MK 8617, MK8617 |
| SMILES | O=C(C1=CN=C(C2=NN=CC=C2)N=C1O)NC(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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Contact information
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