MK-8617

Catalog No.: A12618

pan HIF PHD1-3 inhibitor

MK-8617

MK-8617 Chemical Structure

CAS NO. 1187990-87-9

MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.

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5 mg

Regular Price: $81.00

Special Price $64.80

10 mg

Regular Price: $140.00

Special Price $112.00

50 mg

Regular Price: $414.00

Special Price $331.20

100 mg

Regular Price: $828.00

Special Price $662.40

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Biological Activity

MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.
In vitro DMSO Warmed: 17 mg/mL (38.34 mM)
Water Insoluble
Ethanol 1 mg/mL (2.25 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.55 mL 112.75 mL 225.5 mL
0.5 mM 4.51 mL 22.55 mL 45.1 mL
1 mM 2.26 mL 11.28 mL 22.55 mL
5 mM 0.45 mL 2.26 mL 4.51 mL

*The above data is based on the productmolecular weight 443.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12618
Actions Inhibitor
CAS No. 1187990-87-9
Formula C24H21N5O4
M. Wt 443.45
Purity >98%
Synonyms MK 8617, MK8617
SMILES O=C(C1=CN=C(C2=NN=CC=C2)N=C1O)NC(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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