MK-8745

Catalog No.: A13396
Aurora Kinase A Inhibitor
MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.
Grouped product items
Product Name Price Stock Qty
MK-8745 10mg
$60.00
In stock
MK-8745 25mg
$120.00
In stock
MK-8745 50mg
$180.00
In stock
MK-8745 10mM * 1mL in DMSO
$60.00
In stock
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Biological Activity
Discription MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.
Targets
Target Value
Product Information
Catalog Num A13396
Formula C20H19ClFN5OS
Molecular Weight 431.91
CAS Number 885325-71-3
SMILES ClC1=C(F)C(C(N2CCN(CC3=NC(NC4=NC=CS4)=CC=C3)CC2)=O)=CC=C1
Synonyms MK8745, MK 8745
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 81 mg/mL (187.53 mM)
Water Insoluble
Ethanol 1 mg/mL (2.31 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.15 mL 115.76 mL 231.53 mL
0.5 mM 4.63 mL 23.15 mL 46.31 mL
1 mM 2.32 mL 11.58 mL 23.15 mL
5 mM 0.46 mL 2.32 mL 4.63 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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