MK-8745

Catalog No.: A13396

Aurora Kinase A Inhibitor

MK-8745 Chemical Structure

CAS NO. 885325-71-3

MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.

Availability: In stock

Package Price Qty
10 mg
$60.00
25 mg
$120.00
50 mg
$180.00
10mM * 1mL in DMSO
$60.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.
Targets
Aurora A Aurora B
0.6 nM280 nM
In vitro DMSO 86 mg/mL (199.11 mM)
Water <1 mg/mL (<1 mM)
Ethanol 1 mg/mL (2.31 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.15 mL 115.76 mL 231.53 mL
0.5 mM 4.63 mL 23.15 mL 46.31 mL
1 mM 2.32 mL 11.58 mL 23.15 mL
5 mM 0.46 mL 2.32 mL 4.63 mL

*The above data is based on the productmolecular weight 431.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13396
Actions Inhibitor
M. Wt 431.91
Formula C20H19ClFN5OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 885325-71-3
Synonyms MK8745, MK 8745
SMILES ClC1=C(F)C(C(N2CCN(CC3=NC(NC4=NC=CS4)=CC=C3)CC2)=O)=CC=C1

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