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Biological Activity
MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.
Targets
| Aurora A | Aurora B | |||
| 0.6 nM | 280 nM |
| In vitro | DMSO | 81 mg/mL (187.53 mM) | |
| Water | Insoluble | ||
| Ethanol | 1 mg/mL (2.31 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.15 mL | 115.76 mL | 231.53 mL |
| 0.5 mM | 4.63 mL | 23.15 mL | 46.31 mL |
| 1 mM | 2.32 mL | 11.58 mL | 23.15 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.63 mL |
*The above data is based on the productmolecular weight 431.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13396 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 885325-71-3 |
| Formula | C20H19ClFN5OS |
| M. Wt | 431.91 |
| Purity | >98% |
| Synonyms | MK8745, MK 8745 |
| SMILES | ClC1=C(F)C(C(N2CCN(CC3=NC(NC4=NC=CS4)=CC=C3)CC2)=O)=CC=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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