Fig. 1 · Structure
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MK2-IN-3
MK-2 Inhibitor
MK2-IN-3 is a selective inhibitor of MAPKAP-K2 (MK-2), exhibiting an IC50 of 8.5 nM. This compound demonstrates a strong preference for MK-2 over other kinases, including MK-3, MK-5, and p38a, with significantly higher IC50 values. MK2-IN-3 effectively reduces TNFα production, making it valuable for research into inflammatory responses involving U937 cells and in vivo models. This inhibitor is essential for studies aimed at elucidating the biological pathways regulated by MK-2.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 724711-21-1 |
| Applications | MK-2 Inhibitor |
| Formula | C21H16N4O |
| Molecular Weight | 340.38 |
| SMILES | O=C1C2=C(NC(C3=CC(C4=CC5=CC=CC=C5N=C4)=NC=C3)=C2)CCN1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.